解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean patients with bladder cancer. METHODS:Using population-based data from the Korea Central Cancer Re...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4530-3
更新日期:2018-05-31 00:00:00
abstract:BACKGROUND:Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer related death in the world with a five-year survival rate of less than 5%. Not all PDAC are the same, because there exist intra-tumoral heterogeneity between PDAC, which poses a great challenge to personalized treatments for PDAC. ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4546-8
更新日期:2018-05-29 00:00:00
abstract:BACKGROUND:Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several signaling pathways, including NF-κB, are altered in TNBC, and the complexity of this disease implies ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4507-2
更新日期:2018-05-25 00:00:00
abstract:BACKGROUND:There is increasing appreciation that non-cancer cells within the tumour microenvironment influence cancer progression and anti-cancer drug efficacy. For metastatic prostate cancer (PCa), the bone marrow microenvironment influences metastasis, drug response, and possibly drug resistance. METHODS:Using a nov...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4473-8
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Knowledge about the expression and thus a role of enzymes that produce endogenous H2S - cystathionine-β-synthase, cystathionine γ-lyase and mercaptopyruvate sulfurtransferase - in renal tumors is still controversial. In this study we aimed to determine the expression of these enzymes relatively to the expres...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4508-1
更新日期:2018-05-24 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is a frequent type of primary liver cancer, and its prevalence is increasing worldwide. Indeed, the underlying molecular mechanism is not well understood. Previous studies have shown evidence that tight junction (TJ) components were correlated with carcinogenesis and tumor deve...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4484-5
更新日期:2018-05-18 00:00:00
abstract:BACKGROUND:The objectives of this study were to build a normal tissue complication probability (NTCP) model of radiation-induced hypothyroidism (RHT) for nasopharyngeal carcinoma (NPC) patients and to compare it with other four published NTCP models to evaluate its efficacy. METHODS:Medical notes of 174 NPC patients a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4348-z
更新日期:2018-05-18 00:00:00
abstract:BACKGROUND:Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases risks of urinary and bowel toxicity. Recently the contribution of "spacers" positioned in the septum...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4492-5
更新日期:2018-05-16 00:00:00
abstract:BACKGROUND:A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybribio) which was documented to function accurately in a reduced volume of cervical specimen to determi...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4438-y
更新日期:2018-05-15 00:00:00
abstract:BACKGROUND:High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4475-6
更新日期:2018-05-11 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab. We hypothesized that circulating VEGF-121 may reduce the amount of bevacizumab available to target ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4442-2
更新日期:2018-05-10 00:00:00
abstract:BACKGROUND:While data from several studies over the last decade has demonstrated that introduction of immunologic checkpoint blockage therapy with anti-CTLA-4/PD-1 drugs leads to improved survival in metastatic melanoma patients, relatively little is known about brain-specific therapeutic response and adverse events in...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-4470-y
更新日期:2018-05-09 00:00:00
abstract:BACKGROUND:Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group 3, and Group 4. Macrophages play a crucial role in the tumor microenvironment; however, the functio...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4457-8
更新日期:2018-05-08 00:00:00
abstract:BACKGROUND:Several studies have reported the role of CYP2A6 genetic polymorphisms in smoking and lung cancer risk with some contradictory results in different populations. The purpose of the current study is to assess the contribution of the CYP2A6*2 rs1801272 and CYP2A6*9 rs28399433 gene polymorphisms and tobacco smok...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4342-5
更新日期:2018-05-03 00:00:00
abstract:BACKGROUND:Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length (TL) and colorectal cancer and its precursors, colorectal polyps, is not clear. METHODS:We investigat...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4426-2
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:The fecal immunochemical test (FIT) is easier to use and more sensitive than the guaiac fecal occult blood test, but it is unclear how to optimize FIT performance. We compared the sensitivity and specificity for detecting advanced colorectal neoplasia between single-sample (1-FIT) and two-sample (2-FIT) FIT ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4402-x
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Following the recommendation of lung cancer screening in the US, screening committees in several European countries are reviewing the evidence for implementing national programmes. However, inadequate participation from high-risk groups poses a potential barrier to its effectiveness. The present study examin...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4430-6
更新日期:2018-05-02 00:00:00
abstract:BACKGROUND:Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. Cancer stem cells (CSC) may play critical roles during this process. We aim to demonstrate the role of mesothelioma stem cells (MSC) in treatment failure and eventually to design specific target...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4354-1
更新日期:2018-04-27 00:00:00
abstract:BACKGROUND:Embryonic Liver Fodrin (ELF) is an adaptor protein of transforming growth factor (TGF-β) signaling cascade. Disruption of ELF results in mislocalization of Smad3 and Smad4, leading to compromised TGF-β signaling. c-Myc is an important oncogenic transcription factor, and the disruption of TGF-β signaling prom...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4379-5
更新日期:2018-04-24 00:00:00
abstract:BACKGROUND:Leukemia is different from solid tumor by harboring genetic rearrangements that predict prognosis and guide treatment strategy. PML-RARA, RUNX1-RUNX1T1, and KMT2A-rearrangement are common genetic rearrangements that drive the development of acute myeloid leukemia (AML). By contrast, rare genetic rearrangemen...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4396-4
更新日期:2018-04-23 00:00:00
abstract:BACKGROUND:Previous studies have suggested that metformin may be useful for preventing and treating endometrial cancer (EC), while the results have been inconsistent. This systematic review and meta-analysis aimed to investigate the association between metformin use and risk and prognosis of patients with EC. METHODS:...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1186/s12885-018-4334-5
更新日期:2018-04-18 00:00:00
abstract:BACKGROUND:Metastasis is the main cause of death for lung cancer patients. The ex vivo 4D acellular lung model has been shown to mimic this metastatic process. However, the main concern is the model's lack of cellular components of the tumor's microenvironment. In this study, we aim to determine if the intact lung micr...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4358-x
更新日期:2018-04-18 00:00:00
abstract:BACKGROUND:Survival rates for upper gastrointestinal (GI) cancer are poor since many are diagnosed at advanced stages. Fast track endoscopy has been introduced to prompt diagnosis for patients with alarm symptoms that could be indicative of upper GI cancer. However, these symptoms may represent benign conditions and li...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4376-8
更新日期:2018-04-18 00:00:00
abstract:BACKGROUND:Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. METHODS:Comparative...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4350-5
更新日期:2018-04-17 00:00:00
abstract:BACKGROUND:Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain. It is not clear if other GC-rich binding factors, such as Sp family members, can interact with ZBPp-89 on Bak expression. This study aims to elucidate the mechanism o...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4349-y
更新日期:2018-04-13 00:00:00
abstract::It has been highlighted that in the original manuscript [1] Table S3 'An example of the predictive computational modeling process. Specific details on an annexure section of the PD-L1 pathway show the step-by-step reactions, mechanisms, and reaction equations that occur. Such reactions also occurred in all of the othe...
journal_title:BMC cancer
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12885-018-4200-5
更新日期:2018-04-12 00:00:00
abstract:BACKGROUND:Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versus observation. However, there are few data comparing these approaches. METHODS:This study included ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4305-x
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), is safe for normal brain cells and can kill human glioma cells. This study was further aimed ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4267-z
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, cancer cell plasticity has not yet been described in hematopoietic cancers. To illustrate and study c...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4300-2
更新日期:2018-04-02 00:00:00
abstract:BACKGROUND:The incidence and survival rates for colorectal cancer in Australia are among the highest in the world. With population growth and ageing there are increasing numbers of colorectal cancer survivors in the community, yet little is known of their ongoing follow up and survivorship care experiences. This study ...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4297-6
更新日期:2018-03-27 00:00:00
abstract::Fasting in disease prevention and treatment has recently become a popular topic, particularly in the context of oncology. Unfortunately, the growing attention paid by the media has created a background of speculations and ambiguous messages. The attitude towards the role of fasting in cancer patients should be very ca...
journal_title:BMC cancer
pub_type: 杂志文章,评审
doi:10.1186/s12885-018-4245-5
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast cancer. The current study evaluated the prognostic impact of TOP2A protein on luminal breast cancer....
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4170-7
更新日期:2018-03-27 00:00:00
abstract:BACKGROUND:C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4221-0
更新日期:2018-03-22 00:00:00
abstract:BACKGROUND:To determine the effect of surgery on the survival status of patients with locally advanced cervical cancer after radiotherapy/chemoradiotherapy. METHODS:PubMed, Web of Science, ProQuest and Medline were searched using the key words "cervical cancer", "locally advanced disease", "radiotherapy" and "surgery ...
journal_title:BMC cancer
pub_type: 杂志文章,meta分析
doi:10.1186/s12885-018-4232-x
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Tumor testing for mutations in the epidermal growth factor receptor (EGFR) gene is indicated for all newly diagnosed, metastatic lung cancer patients, who may be candidates for first-line treatment with an EGFR tyrosine kinase inhibitor. Few studies have analyzed population-level testing. METHODS:We identif...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4190-3
更新日期:2018-03-20 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract and liver and peritoneum are the main sites of recurrence. Ovarian metastases from GIST are very rare. CASE PRESENTATION:A 50 years-old woman was found to have a pelvic mass on transvaginal ultrasound...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4204-1
更新日期:2018-03-16 00:00:00
abstract:BACKGROUND:Mutations activating the α subunit of heterotrimeric Gs protein are associated with a number of highly specific pathological molecular phenotypes. One of the best characterized is the McCune Albright syndrome. The disease presents with an increased incidence of neoplasias in specific tissues. MAIN BODY:A si...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4133-z
更新日期:2018-03-15 00:00:00
abstract:BACKGROUND:Breast cancer is one of the leading causes of death in women worldwide. Fast growth is the important character of breast cancer, which makes sure the subsequent metastasize and invasion breast cancer. Golgi related genes GOLPH3 has been reported to regulate many kinds of cancers proliferation. However, its u...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4031-4
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:Patients suffering from squamous cell carcinoma of the larynx (LSCC) with lymphatic metastasis have a relatively poor prognosis and often require radical therapeutic management. The mechanisms which drive metastasis to the lymph nodes are largely unknown but may be promoted by a pro-angiogenic tumor microenv...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4180-5
更新日期:2018-03-09 00:00:00
abstract:BACKGROUND:CD73 is one of the critical component in the formation of immunosuppressive microenvironment in cancers. We aimed to provide an overview of the current status of CD73 expression and its relationship with clinicopathlogical features and prognosis in different cancers. METHODS:PubMed, Web of Science, EMBASE a...
journal_title:BMC cancer
pub_type: 杂志文章
doi:10.1186/s12885-018-4073-7
更新日期:2018-03-07 00:00:00